Acid Related Diseases: Biology and Treatment by Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD

By Irvin M. Modlin MD PhD FRCS(Ed) FRCS(E, George Sachs MD ChB DSc

This textbook explores the heritage, biology, and remedy of acid comparable ailments, together with gastric and duodenal ulcer illness, gastroesophageal reflux disorder (GERD), and the function of H. pylori. The textual content bargains thorough assurance of the subject material, with an in-depth ancient and organic concentration. equivalent concentration is given to the biology and pharmacology of acid secretion and to the explicit illness states of ulcers and GERD. This variation is stuffed with new full-color scientific illustrations of all points of this topic.

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Claros MG, von Heijne G. TopPred II, an improved software for membrane protein structure predictions. Comput Appl Biosci 1994;10:685-686. Celsus AC. Of the disorders of the stomach and their cures. In: De Medicina, book IV. London: Wilson and Durham, 1756:196-201. Griene J, translator. Cyrklaff M, Auer M, Kuhlbrandt W, et al. 2-D structure of the Neurospora crassa plasma membrane ATPase as determined by electron cryomicroscopy. EMBO J 1995;14:1854-1857. Davies RE. The mechanism of hydrochloric acid production by the stomach.

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Experimental evidence for the reaction cycle described above has been obtained using rapid kinetic analysis of the rate of formation and destruction of phosphoenzyme generated from 32P-ATP at different pH and potassium concentrations. The rate of formation of the phosphoenzyme and the K+-dependent rate of breakdown are sufficiently fast to allow the phosphoenzyme to be an intermediate in the overall ATPase reaction. The initial step is the reversible binding of ATP to the enzyme in the absence of added K+ ion, followed by a Mg2+- (and proton-) dependent transfer of the terminal phosphate of ATP to the catalytic subunit (E1-P•H+).

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